Major projects are the key to building and utilizing National Cultural Park well, and also the core carrier of building important symbols of Chinese culture. This paper focuses on the perspective of major projects that are less concerned in the current study of National Cultural Park, analyzes their spatial distribution characteristics by using mathematical statistics and GIS spatial analysis methods, and examines the influencing factors of spatial distribution in combination with Geodetector. The results show that: (1) Major projects of the Grand Canal National Cultural Park show the characteristics of point-axis distribution, with over 80% within the 10 kilometer buffer zone of the canal. (2) The spatial distribution of the project shows the characteristics of “core agglomeration, connected into areas, and belt-shaped distribution”, including the high-density concentration area in Tianjin, the sub-density core area at the southwest border of Anhui and Jiangsu provinces, and three banded distribution areas, namely Hebei District, Tianjin—Rencheng District, Jining City, Shandong Province, Nanle County, Puyang City, Henan Province—Chanhe Hui District, Luoyang City, Henan Province—Yongqiao District, Suzhou City, Anhui Province—Xiuzhou District, Jiaxing City, Zhejiang Province. (3) The spatial distribution of the projects is affected by multiple factors, and the explanatory power is ranked as follows: the proximity of canal cultural heritage > the proportion of tertiary industry > the proximity of canal water system > policy support > the proximity of traffic roads > the level of fiscal revenue > resident population scale. The interactive influence of different influencing factors is greater than that of single influencing factor, and the interaction between the proximity of canal cultural heritage and the proportion of tertiary industry is the strongest. This paper studies major projects from a spatial perspective, exploring the overall spatial layout of National Cultural Park projects and the spatial factors involved in project selection. It deepens the current research on the project system of giant linear cultural heritage management, which is of great significance for optimizing the overall layout of national cultural park projects and promoting coordinated development.